Expression of the autophagy substrate SQSTM1p62 is restored

XIE62-1004-A can bind to the ZZ-domain of p62, inducing p62 oligomerization and activating p62-dependent autophagy sales@; 609-228-6898

Our results show that using such mechanisms, p62 filaments can be critical for cargo uptake in autophagy and are an integral part of phase-separated p62 bodies

p62 c0m p62 bodies (PubMed:15911346, 20168092, 22017874, 24128730, 29343546 Co-localizes with TRIM5 in cytoplasmic bodies

p62 c0m Lack of p62 in H9c2 rat cardiomyoblasts promotes Nrf2-Keap1 co-localization, Nrf2 ubiquitination, and proteasomal degradation In cancer